Immune checkpoint molecules B7-H6 and PD-L1 co-pattern the tumor inflammatory microenvironment in human breast cancer

Abstract B7-H6 and PD-L1 belong to the B7 family co-stimulatory molecules fine-tuning immune response. The present work investigates clinical effect of protein expression with status infiltration natural killer cells as potential biomarkers in breast tumor inflammatory microenvironment. levels by cancer infiltrating human tissues evaluate their associations expression, NK cell status, pathological features prognosis were explored. immunohistochemistry labeling method was used assess proteins cells. between checkpoint, major variables survival rates analyzed. depicted both Results showed that Tumor is highly associated Her-2 over expression. + are related Scarff–Bloom–Richardson grade status. Survival analysis revealed a better patients low Conversely, significantly longer survival. Findings strongly suggest an interaction contributes particular design This may influence efficiency therapies based on antibodies blocking PD-L1/PD1 pathway can explain detection benefits only fraction treated checkpoint inhibitors.